Elucidating the mechanism of cellular
These findings are exciting in the sense that m RNAs were thought to serve primarily as templates for protein production, rather than directly affecting cellular processes.
The mechanism typically involved in protein creation does not apply to all produced RNAs of a cell: particular RNAs do not encode protein information, but instead perform certain functions in fine-tuning gene expression in their form as an RNA molecule.
In cases of advanced dental caries, few alternative options exist other than removing the tooth completely.
Bacteria cause tooth decay Tooth decay is caused by dental plaque, which mainly consists of bacterial biofilm, forming on and around the teeth.
An imbalanced microbiome (termed dysbiosis) can have strong effects on health, with one example of this being dental caries (tooth decay).
This is a major health problem worldwide, affecting 60–90% of schoolchildren and more than 95% of adults.
Dr Justin Merritt, from the Oregon Health & Science University, studies disease-causing bacteria at mucosal sites in humans, especially in the mouth.
Studying disease-related processes in harmful bacteria will not only advance our understanding of those microorganisms, but could ultimately deliver novel therapeutic targets to tackle illnesses.
TNFα-induced programmed necrosis is a caspase-independent cell death program that is contingent upon the formation of a multiprotein complex termed the necrosome.
The association of two of the components of the necrosome, receptor interacting protein 1 (RIP1) and RIP3, is a critical and signature molecular event during necrosis.
I was interested in identifying other regulators of necrosis in hope of gaining a better understanding of the necrosis signaling pathway and regulators of the necrosome.
To address this, I screened a cancer gene si RNA library in a cell line sensitive to necrosis.